In a rat model, FOSRENOL® has been shown to remove more dietary phosphate than either sevelamer hydrochloride or calcium carbonate1,2
aStudy design2: 5/6th nephrectomized rats were dosed daily for 6 weeks with lanthanum carbonate, sevelamer hydrochloride, aluminum hydroxide, calcium carbonate, or vehicle (all at 1000 mg/kg/day) by oral gavage. Twenty four-hour urinary phosphate excretion was used as a marker of dietary binding and intestinal absorption of phosphorus.
bValues are mean ±SEM (n=8). Reductions in phosphorus excretion were significantly greater for lanthanum carbonate than for sevelamer hydrochloride and calcium carbonate (P<.05).
- Reduction in the urinary excretion of phosphorus in rats was significantly greater with FOSRENOL® compared with sevelamer hydrochloride or calcium carbonate
- Reduction in urinary phosphorus to near zero was observed after 2 weeks of FOSRENOL® treatment and was maintained throughout the study
- The relationship of these findings in animals to the effects of FOSRENOL® in humans has not been established. No comparisons can be made at this time
- The information and graphics on this page are not intended to show a comparison of clinical efficacy or safety in humans